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Cat. No.: HY-178361

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Remodelin-C6-COOH

Remodelin-C6-COOH is a synthesized target protein ligand-linker conjugate that can be used for synthesis of NP1192 (HY-178360). NP1192 is a potent NAT10 PROTAC degrader with anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 2966791-35-3
Formula: C₂₂H₂₆N₄O₂S
Molecular Weight:410.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Remodelin-C6-COOH Chemical Structure

CAS No.: 2966791-35-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Remodelin-C6-COOH is a synthesized target protein ligand-linker conjugate that can be used for synthesis of NP1192 (HY-178360). NP1192 is a potent NAT10 PROTAC degrader with anti-tumor activity^[1].

Chemical Information

CAS No. 2966791-35-3
Molecular Weight 410.53
Formula C₂₂H₂₆N₄O₂S
SMILES

N#CC1=CC=C(C=C1)C2=CSC(N(/N=C3CCCC/3)CCCCCCC(O)=O)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ao, K., et al. Targeted NAT10 Degradation by PROTAC NP1192 Suppresses Hypoxia-Adaptive Glycolysis and Reinvigorates CD8+ Effector T-Cell Function for Synergistic Cancer Immunotherapy. ACS Central Science. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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