OZD-MET 01
OZD-MET 01 is a chaperone-med iatedprotein PROTAC-type MET degrader. OZD-MET 01 can inhibit proliferation of H596 and H1437 cells with IC50 values of 3.07 and 3.5 μM. OZD-MET 01 can be used for the research of cancer, such as non-small cell lung cancer. (Structure Note: Pink: MET ligand (HY-50878); Blue: chaperone ligand (HY-112078); MET ligand-Linker: (HY-176950))
(Pink: c-Met/HGFR ligand (HY-50878); Blue: HSP90 ligand (HY-176951); Black: linker (HY-176952)).
For research use only. We do not sell to patients.
- CAS No.: 3048497-38-4
- Formula: C45H50Cl2FN7O8
- Molecular Weight:906.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
OZD-MET 01 (5 μM, 72 h) induces degradation of MET protein in H596 and H1437 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3048497-38-4
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Molecular Weight 906.83
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Formula C45H50Cl2FN7O8
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SMILES
C[C@@H](OC1=CC(C2=CN(N=C2)C3CCN(C(OCCOCCNC(C4=CC(CN(C(C5=CC(C(C)C)=C(O)C=C5O)=O)C)=CC=C4)=O)=O)CC3)=CN=C1N)C6=C(Cl)C(F)=CC=C6Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OZD-MET 01 Related Classifications
HY-177893 Related Classifications
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