3048497-38-4
Chemical Structure
OZD-MET 01
- CAS No.: 3048497-38-4
- Formula:C45H50Cl2FN7O8
- Molecular Weight:906.83
InChIKey: OFMNSOFELBXNIT-HHHXNRCGSA-N
SMILES: C[C@@H](OC1=CC(C2=CN(N=C2)C3CCN(C(OCCOCCNC(C4=CC(CN(C(C5=CC(C(C)C)=C(O)C=C5O)=O)C)=CC=C4)=O)=O)CC3)=CN=C1N)C6=C(Cl)C(F)=CC=C6Cl
Biological Activity: OZD-MET 01 is a chaperone-med iatedprotein PROTAC-type MET degrader. OZD-MET 01 can inhibit proliferation of H596 and H1437 cells with IC50 values of 3.07 and 3.5 μM. OZD-MET 01 can be used for the research of cancer, such as non-small cell lung cancer[1]. (Structure Note: Pink: MET ligand (HY-50878); Blue: chaperone ligand (HY-112078); MET ligand-Linker: (HY-176950))
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OZD-MET 01 | OZD-MET 01 is a chaperone-med iatedprotein PROTAC-type MET degrader. OZD-MET 01 can inhibit proliferation of H596 and H1437 cells with IC50 values of 3.07 and 3.5 μM. OZD-MET 01 can be used for the research of cancer, such as non-small cell lung cancer. (Structure Note: Pink: MET ligand (HY-50878); Blue: chaperone ligand (HY-112078); MET ligand-Linker: (HY-176950)) | |||||||||||||||||||||
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Keywords
