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Cat. No.: HY-178510

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JQ1-S(GlcNAc)Cq

JQ1-S(GlcNAc)Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S(GlcNAc)Cq can inhibit the formation of the ternary complex between CRBN and BRD4(BD1/BD2). JQ1-S(GlcNAc)Cq can be used for the research of cancer. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-178514); Black: linker (HY-W105727); BRD4 ligand-Linker: (HY-178519))
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon E3 ligase ligand; Black: linker (HY-W105727)).

For research use only. We do not sell to patients.

Formula: C₄₄H₅₈ClN₉O₁₁S
Molecular Weight:956.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

JQ1-S(GlcNAc)Cq Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JQ1-S(GlcNAc)Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S(GlcNAc)Cq can inhibit the formation of the ternary complex between CRBN and BRD4(BD1/BD2). JQ1-S(GlcNAc)Cq can be used for the research of cancer^[1]. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-178514); Black: linker (HY-W105727); BRD4 ligand-Linker: (HY-178519)) (Pink: BRD4 ligand (HY-78695); Blue: Cereblon E3 ligase ligand; Black: linker (HY-W105727)).

IC₅₀ & Target^[1]

Cereblon

BRD4(BD1BD2)

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

JQ1-S(GlcNAc)cQ significantly inhibits the formation of the ternary complex between CRBN and BRD4(BD1/BD2)^[1].
JQ1-S(GlcNAc)cQ induce BRD4 degradation in HEK293T cells with a DC₅₀ of 2.1 μM^[1].
JQ1-S(GlcNAc)cQ inhibits cell growth in HEK293T cells with a GI₅₀ >316 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

0.1, 0.4, 1.1, 3.3 and 10 μM
Incubation Time:

12 h
Result:

Reduced α-BRD4 expression.

Chemical Information

Molecular Weight 956.50
Formula C₄₄H₅₈ClN₉O₁₁S
SMILES

O=C(N1)[C@@H](NC([C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)NC(CCCCCCCCNC(C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N6C3=NN=C6C)=O)=O)=O)CCC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu Q, et al. Enzyme-Activated Sugar-Coated Bifunctional Degraders. J Am Chem Soc. 2025 Sep 24;147(38):34672-34680. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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JQ1-S(GlcNAc)Cq

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JQ1-S(GlcNAc)Cq Related Classifications

HY-178510 Related Classifications