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Cat. No.: HY-160221

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PROTAC AR Degrader-7

PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC₅₀ value of 3 nM.
(Pink: Androgen Receptor ligand (HY-170303); Blue: VHL ligand (HY-170304); Black: linker (HY-30105)).

For research use only. We do not sell to patients.

CAS No.: 2505495-83-8
Formula: C₄₁H₄₁ClFN₉O₆
Molecular Weight:810.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

PROTAC AR Degrader-7 Chemical Structure

CAS No.: 2505495-83-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC₅₀ value of 3 nM^[1]. (Pink: Androgen Receptor ligand (HY-170303); Blue: VHL ligand (HY-170304); Black: linker (HY-30105)).

All PROTACs Isoforms :

Chemical Information

CAS No. 2505495-83-8
Molecular Weight 810.27
Formula C₄₁H₄₁ClFN₉O₆
SMILES

O=C(C1=NC=C(N2CCN(C[C@@H]3[C@]4([H])[C@@]3([H])CN(C5=CC6=C(C(N(C7CCC(NC7=O)=O)C6=O)=O)C=C5F)C4)CC2)N=C1)N[C@H]8CC[C@H](OC9=CC=C(C#N)C(Cl)=C9)CC8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. DU wu,et al. Dual-function chimeric heterocyclic compound for targeted degradation of androgen receptor and application thereof. CN111825657A. 2020.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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PROTAC AR Degrader-7

All PROTACs Isoforms