1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Pomalidomide 4'-PEG2-azide

Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Pomalidomide 4'-PEG2-azide Chemical Structure

Pomalidomide 4'-PEG2-azide Chemical Structure

CAS No. : 2271036-45-2

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Description

Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

430.41

Formula

C19H22N6O6

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN=[N+]=[N-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3234 mL 11.6168 mL 23.2337 mL
5 mM 0.4647 mL 2.3234 mL 4.6467 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3234 mL 11.6168 mL 23.2337 mL 58.0842 mL
5 mM 0.4647 mL 2.3234 mL 4.6467 mL 11.6168 mL
10 mM 0.2323 mL 1.1617 mL 2.3234 mL 5.8084 mL
15 mM 0.1549 mL 0.7745 mL 1.5489 mL 3.8723 mL
20 mM 0.1162 mL 0.5808 mL 1.1617 mL 2.9042 mL
25 mM 0.0929 mL 0.4647 mL 0.9293 mL 2.3234 mL
30 mM 0.0774 mL 0.3872 mL 0.7745 mL 1.9361 mL
40 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.4521 mL
50 mM 0.0465 mL 0.2323 mL 0.4647 mL 1.1617 mL
60 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9681 mL
80 mM 0.0290 mL 0.1452 mL 0.2904 mL 0.7261 mL
100 mM 0.0232 mL 0.1162 mL 0.2323 mL 0.5808 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pomalidomide 4'-PEG2-azide
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