2. PI3K/Akt/mTOR PROTAC Autophagy
  3. Autophagy PIKfyve PROTACs
  4. PIK5-12d

PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d has anti-tumor activity.

For research use only. We do not sell to patients.

PIK5-12d Chemical Structure

PIK5-12d Chemical Structure

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 910 In-stock
Solution
10 mM * 1 mL in DMSO USD 910 In-stock
Solid
1 mg USD 250 In-stock
5 mg USD 530 In-stock
10 mg USD 850 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

PIK5-12d Related Antibodies

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Description

PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d has anti-tumor activity[1].

Molecular Weight

973.19

Formula

C52H64N10O7S
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=CC=CC(/C=N/NC2=NC(OCCC3=CC=C(NC(CCCCC(N[C@H](C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)C(C)(C)C)=O)=O)C=C3)=NC(N7CCOCC7)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (205.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0275 mL 5.1377 mL 10.2755 mL
5 mM 0.2055 mL 1.0275 mL 2.0551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0275 mL 5.1377 mL 10.2755 mL 25.6887 mL
5 mM 0.2055 mL 1.0275 mL 2.0551 mL 5.1377 mL
10 mM 0.1028 mL 0.5138 mL 1.0275 mL 2.5689 mL
15 mM 0.0685 mL 0.3425 mL 0.6850 mL 1.7126 mL
20 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2844 mL
25 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0275 mL
30 mM 0.0343 mL 0.1713 mL 0.3425 mL 0.8563 mL
40 mM 0.0257 mL 0.1284 mL 0.2569 mL 0.6422 mL
50 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5138 mL
60 mM 0.0171 mL 0.0856 mL 0.1713 mL 0.4281 mL
80 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.3211 mL
100 mM 0.0103 mL 0.0514 mL 0.1028 mL 0.2569 mL
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PIK5-12d Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIK5-12dAutophagyPIKfyvePROTACsFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1Inhibitorinhibitorinhibit

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