2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip

RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip is a Ligand-Linker conjunction, targeting RIPK1. RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip can be used to synthesize PROTAC LD5097 (HY-179234).

For research use only. We do not sell to patients.

RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip

RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip Chemical Structure

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RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip Related Antibodies

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Description

RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip is a Ligand-Linker conjunction, targeting RIPK1. RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip can be used to synthesize PROTAC LD5097 (HY-179234)[1].

In Vitro

RIPK1 PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand, and the other is for Ligands of RIPK1 target protein (RIPK1-IN-37) (HY-179235). The Ligand-Linker conjunction (RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip) (HY-179242) formed by the ligation of Ligands and the linker can form PROTAC LD5097 (HY-179234) with the E3 ligase ligand. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip Related Antibodies
Molecular Weight

825.88

Formula

C46H42F3N9O3
SMILES

O=C(N1CCC2=C1C=CC(C3=CN(C4=NC=NC(N)=C34)C5CCN(CC5)C(C6=CC=C(C=C6)C#CC7=CN=C(C=C7)N8CCNCC8)=O)=C2)CC9=CC=CC(OC(F)(F)F)=C9
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-37-CO-Ph-alkynyl-Py-PipTarget Protein Ligand-Linker ConjugatesRIPK1 DegradersPROTACJurkat Xenograft ModelInhibitorinhibitorinhibit

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Product Name:
RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip
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HY-179242
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