Ceritinib-amide-C3-acid
Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970).
For research use only. We do not sell to patients.
- CAS No.: 2162120-74-1
- Formula: C33H42ClN5O6S
- Molecular Weight:672.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2162120-74-1
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Molecular Weight 672.23
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Formula C33H42ClN5O6S
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SMILES
CC(C)OC(C=C(C1CCN(CC1)C(CCCC(O)=O)=O)C(C)=C2)=C2NC3=NC=C(Cl)C(NC4=C(C=CC=C4)S(C(C)C)(=O)=O)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kang CH, et al. Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC). Biochem Biophys Res Commun. 2018 Oct 28;505(2):542-547. [Content Brief]
[2]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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