2162120-74-1
2162120-74-1
Chemical Structure
Ceritinib-amide-C3-acid
- CAS No.: 2162120-74-1
- Formula:C33H42ClN5O6S
- Molecular Weight:672.23
InChIKey: HMBWKACNJMPDIG-UHFFFAOYSA-N
SMILES: CC(C)OC(C=C(C1CCN(CC1)C(CCCC(O)=O)=O)C(C)=C2)=C2NC3=NC=C(Cl)C(NC4=C(C=CC=C4)S(C(C)C)(=O)=O)=N3
Biological Activity: Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ceritinib-amide-C3-acid | Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Kang CH, et al. Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC). Biochem Biophys Res Commun. 2018 Oct 28;505(2):542-547. [Content Brief]
- [2]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]
