SJ10542
Based on 1 Customer Validation
SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC50 values of 14 and 11 nM for JAK2 and JAK3, respectively. SJ10542 exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases.
(Pink: JAK2 and JAK3 Target protein ligand; Blue: Cereblon ligand (HY-W890189); Black: linker).
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- Pureté: 99.32%
- CAS No.: 2789678-92-6
- Formule: C41H46N12O5S
- Masse moléculaire:818.95
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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JAK2 14 nM (DC50) |
JAK3 11 nM (DC50) |
JAK2-fusion ALL 24 nM (DC50) |
Cereblon |
SJ10542 (1-9000 nM; 24 h) potently degrades JAK2 (DC50: 24 nM), JAK3 and GSPT1 in MHH-CALL-4 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MHH-CALL-4 cells
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Concentration:1, 10, 100, 1000 and 9000 nM
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Incubation Time:24 h
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Result:Inhibited the levels of JAK2, JAK3 and GSPT1 in a dose-dependent manner.
Chemical Information
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CAS No. 2789678-92-6
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Appearance Solid
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Masse moléculaire 818.95
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Formule C41H46N12O5S
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Color White to off-white
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SMILES
O=C(C1=CC=C(NC2=NC(NC=C3)=C3C(C4=CN(C5(CN(S(=O)(CC)=O)C5)CC#N)N=C4)=N2)C=C1)NCCCN(CC6)CCN6C7=CC=C(C=C7)C8C(NC(CC8)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 46.67 mg/mL (56.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.2211 mL | 6.1054 mL | 12.2108 mL | 30.5269 mL |
| 5 mM | 0.2442 mL | 1.2211 mL | 2.4422 mL | 6.1054 mL | |
| 10 mM | 0.1221 mL | 0.6105 mL | 1.2211 mL | 3.0527 mL | |
| 15 mM | 0.0814 mL | 0.4070 mL | 0.8141 mL | 2.0351 mL | |
| 20 mM | 0.0611 mL | 0.3053 mL | 0.6105 mL | 1.5263 mL | |
| 25 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.2211 mL | |
| 30 mM | 0.0407 mL | 0.2035 mL | 0.4070 mL | 1.0176 mL | |
| 40 mM | 0.0305 mL | 0.1526 mL | 0.3053 mL | 0.7632 mL | |
| 50 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.6105 mL |
SJ10542 Related Classifications
HY-145696 Related Classifications
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