2. PROTAC
  3. Ligands for E3 Ligase
  4. E3 ligase Ligand-Linker Conjugate 40

E3 ligase Ligand-Linker Conjugate 40 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 40 can be used as a key intermediate for the synthesis of complete PROTAC molecules.

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E3 ligase Ligand-Linker Conjugate 40 Chemical Structure

E3 ligase Ligand-Linker Conjugate 40 Chemical Structure

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E3 ligase Ligand-Linker Conjugate 40 Related Antibodies

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Description

E3 ligase Ligand-Linker Conjugate 40 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 40 can be used as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

von Hippel-Lindau (VHL)[1]
Molecular Weight

723.93

Formula

C37H53N7O6S
SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CN2CC3(CN(C3)CC4CCN(CC4)CC(O)=O)C2)=O)=O)NCC(C=C5)=CC=C5C(SC=N6)=C6C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E3 ligase Ligand-Linker Conjugate 40 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand-Linker Conjugate 40Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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