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Cat. No.: HY-183072

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(S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH

(S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH (Compound 12) is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand (HY-170348) and a PROTAC linker (HY-W586116). (S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH can be used for synthesis of PROTAC, such as CXJ2080 (HY-183070).

For research use only. We do not sell to patients.

Formula: C₃₂H₄₄N₆O₅S
Molecular Weight:624.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 624.79
Formula C₃₂H₄₄N₆O₅S
SMILES

O=C([C@H]1N(C([C@@H](N2N=NC(CCCCCCC(O)=O)=C2)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tu Y, et al. Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity. Leukemia. Published online March 25, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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