DCAF11 ligand-Linker Conjugate 1
DCAF11 ligand-Linker Conjugate 1 is a conjugate of a DCAF11 ligand and a linker. DCAF11 ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC LGF308 (HY-181756).
For research use only. We do not sell to patients.
- CAS No.: 3061406-50-3
- Formula: C16H19N3O4S
- Molecular Weight:349.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
DCAF11 ligand-Linker Conjugate 1 (compound 13j) (10 μM; 9 h) does not induce BRD4 degradation in MDA-MB-231 cells by itself[1].
DCAF11 ligand-Linker Conjugate 1 (10 μM) does not induce apoptosis in MDA-MB-231 cells, whereas the corresponding PROTAC (LGF308) potently activates the apoptotic pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:10 μM
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Incubation Time:9 h
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Result:Did not induce significant degradation of BRD4 protein in MDA-MB-231 cells.
Chemical Information
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CAS No. 3061406-50-3
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Molecular Weight 349.40
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Formula C16H19N3O4S
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SMILES
O=C(N1CCCCCCN)/C(SC1=O)=C/C2=CC([N+]([O-])=O)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DCAF11 ligand-Linker Conjugate 1 Related Classifications
HY-181757 Related Classifications
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