2. PROTAC Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Apoptosis
  4. DCAF11 ligand-Linker Conjugate 1

DCAF11 ligand-Linker Conjugate 1 is a conjugate of a DCAF11 ligand and a linker. DCAF11 ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC LGF308 (HY-181756).

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DCAF11 ligand-Linker Conjugate 1

DCAF11 ligand-Linker Conjugate 1 Chemical Structure

CAS No. : 3061406-50-3

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DCAF11 ligand-Linker Conjugate 1 Related Antibodies

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Description

DCAF11 ligand-Linker Conjugate 1 is a conjugate of a DCAF11 ligand and a linker. DCAF11 ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC LGF308 (HY-181756)[1].

In Vitro

DCAF11 ligand-Linker Conjugate 1 (compound 13j) (10 μM; 9 h) does not induce BRD4 degradation in MDA-MB-231 cells by itself[1].
DCAF11 ligand-Linker Conjugate 1 (10 μM) does not induce apoptosis in MDA-MB-231 cells, whereas the corresponding PROTAC (LGF308) potently activates the apoptotic pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCAF11 ligand-Linker Conjugate 1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 10 μM
Incubation Time: 9 h
Result: Did not induce significant degradation of BRD4 protein in MDA-MB-231 cells.
Molecular Weight

349.40

Formula

C16H19N3O4S
CAS No.
SMILES

O=C(N1CCCCCCN)/C(SC1=O)=C/C2=CC([N+]([O-])=O)=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DCAF11 ligand-Linker Conjugate 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCAF11 ligand-Linker Conjugate 13061406-50-3E3 Ligase Ligand-Linker ConjugatesApoptosisDCAF11ternary complexMDA-MB-231 cellsPROTACJQ1BRD4apoptosisapoptotic pathwaysInhibitorinhibitorinhibit

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