E3 Ligase Ligand-linker Conjugate 101
E3 Ligase Ligand-linker Conjugate 101 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 Ligase Ligand-linker Conjugate 101 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
For research use only. We do not sell to patients.
- Formula: C34H49N5O6S
- Molecular Weight:655.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
von Hippel-Lindau (VHL)[1]
Chemical Information
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Molecular Weight 655.85
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Formula C34H49N5O6S
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SMILES
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(C2CCN(CC2)CC(OC(C)(C)C)=O)=O)=O)NCC(C=C3)=CC=C3C(SC=N4)=C4C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019. [Content Brief]
[2]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E3 Ligase Ligand-linker Conjugate 101 Related Classifications
HY-157752 Related Classifications
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