Thalidomide-piperazine hydrochloride
Based on 1 Customer Validation
Thalidomide-piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprising a cereblon ligand based on Thalidomide (HY-14658) and one linker. Thalidomide-piperazine hydrochloride can be used in studies related to PROTAC synthesis.
For research use only. We do not sell to patients.
- Purity: 98.27%
- CAS No.: 2228029-82-9
- Formula: C17H19ClN4O4
- Molecular Weight:378.81
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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E3 Ligase Ligand Library
HY-L128
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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Molecular Glue-like Compound Library
HY-L918
Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2228029-82-9
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Appearance Solid
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Molecular Weight 378.81
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Formula C17H19ClN4O4
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Color Light yellow to green yellow
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CCNCC4)=C3)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 33.33 mg/mL (87.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[2]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014;512(7512):49-53. [Content Brief]
[3]. Monsen PJ, et al. Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025;68(4):4961-4987. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6398 mL | 13.1992 mL | 26.3985 mL | 65.9961 mL |
| 5 mM | 0.5280 mL | 2.6398 mL | 5.2797 mL | 13.1992 mL | |
| 10 mM | 0.2640 mL | 1.3199 mL | 2.6398 mL | 6.5996 mL | |
| 15 mM | 0.1760 mL | 0.8799 mL | 1.7599 mL | 4.3997 mL | |
| 20 mM | 0.1320 mL | 0.6600 mL | 1.3199 mL | 3.2998 mL | |
| 25 mM | 0.1056 mL | 0.5280 mL | 1.0559 mL | 2.6398 mL | |
| 30 mM | 0.0880 mL | 0.4400 mL | 0.8799 mL | 2.1999 mL | |
| 40 mM | 0.0660 mL | 0.3300 mL | 0.6600 mL | 1.6499 mL | |
| 50 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3199 mL | |
| 60 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.0999 mL | |
| 80 mM | 0.0330 mL | 0.1650 mL | 0.3300 mL | 0.8250 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thalidomide-piperazine hydrochloride Related Classifications
HY-132971 Related Classifications
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