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Cat. No.: HY-W834174

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Thalidomide-5-piperazine

Thalidomide-5-piperazine is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC BRD9 Degrader-7 (HY-155361).

For research use only. We do not sell to patients.

CAS No.: 2154342-61-5
Formula: C₁₇H₁₈N₄O₄
Molecular Weight:342.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide-5-piperazine Chemical Structure

CAS No.: 2154342-61-5

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Sample (0.1mg)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Thalidomide-5-piperazine is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC BRD9 Degrader-7 (HY-155361)^[1].

IC₅₀ & Target

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2154342-61-5
Molecular Weight 342.35
Formula C₁₇H₁₈N₄O₄
SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCNCC4)C=C3C2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jingyu Zhang, et al. Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia, European Journal of Medicinal Chemistry, Volume 262, 2023, 115872. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Thalidomide-5-piperazine

All E3 Ligase Ligand-Linker Conjugates Isoforms

All Ligands for E3 Ligase Isoforms