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Isoforms Recommended: Cleavable Linker
Results for "

cleavable linker

" in MedChemExpress (MCE) Product Catalog:

898

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21

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9

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21

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1

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17

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3

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Products

3

Isotope-Labeled Compounds

235

Click Chemistry

1

Oligonucleotides

7

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114697
    DSG Crosslinker
    4 Publications Verification

    Disuccinimidyl glutarate

    Biochemical Assay Reagents Inflammation/Immunology
    DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.
    DSG Crosslinker
  • HY-118759
    DSP Crosslinker
    2 Publications Verification

    Biochemical Assay Reagents Inflammation/Immunology
    DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.
    DSP Crosslinker
  • HY-41189

    ADC Linkers Cancer
    Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers .
    Fmoc-Val-Cit-PAB-PNP
  • HY-131990

    ADC Linkers Cancer
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
  • HY-44222

    ADC Linkers Cancer
    MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    MAC glucuronide linker-2
  • HY-164239

    Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, consisting of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE) (HY-15162). NH2-PEG3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs) .
    NH2-PEG3-VC-PAB-MMAE
  • HY-44235

    ADC Linkers Cancer
    MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).
    MC-Gly-Gly-Phe
  • HY-101162

    Drug-Linker Conjugates for ADC Cancer
    SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala .
    SGD-1910
  • HY-116063
    Doxorubicin-SMCC
    1 Publications Verification

    Drug-Linker Conjugates for ADC Cancer
    Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin .
    Doxorubicin-SMCC
  • HY-131157

    ADC Linkers Cancer
    Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs) . Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Lys(MMT)-PAB-oxydiacetamide-PEG8-N3
  • HY-P99101

    AEX-4089; MGC026 antibody

    ADC Antibodies Cancer
    Vobramitamab is a humanized B7-H3 monoclonal antibody (mAb). Vobramitamab conjugated with prodrug seco-DUBA (HY-132180A) via a cleavable linker, to form antibody-drug conjugate (ADC), the MGC018. MGC018 displays potent antitumor activity in preclinical tumor models of breast, ovarian, and lung cancer, as well as melanoma .
    Vobramitamab
  • HY-140150

    ADC Linkers PROTAC Linkers Cancer
    Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Val-Cit-PAB-PNP
  • HY-130184

    ADC Linkers PROTAC Linkers Cancer
    Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-NHS ester
  • HY-148461

    ADC Linkers Cancer
    Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-VC-PAB-PNP
  • HY-148462

    ADC Linkers Cancer
    Fmoc-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-Ala-Ala-PAB
  • HY-148464

    ADC Linkers Cancer
    MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
    MC-Ala-Ala-PAB
  • HY-21577

    ADC Linkers PROTAC Linkers Cancer
    Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
    Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
  • HY-125933

    ADC Linkers Cancer
    Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis .
    Val-Ala-PAB
  • HY-101151

    ADC Linkers Cancer
    sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    sulfo-SPDB
  • HY-135418

    ADC Linkers Cancer
    Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Fmoc-Asp-NH2
  • HY-126498

    ADC Linkers Cancer
    PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).
    PDEC-NB
  • HY-12448

    ADC Linkers Cancer
    SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
    SPDB
  • HY-117519

    ADC Linkers PROTAC Linkers Cancer
    Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Amino-Tri-(carboxyethoxymethyl)-methane
  • HY-P3159

    Biochemical Assay Reagents Others
    VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel .
    VPM peptide
  • HY-130474

    ADC Linkers PROTAC Linkers Cancer
    Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-NHS ester
  • HY-139441

    Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936 .
    DM21
  • HY-126494

    Drug-Linker Conjugates for ADC Cancer
    DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker .
    DM4-SMCC
  • HY-128926
    SPP
    1 Publications Verification

    N-succinimidyl 4-(2-pyridyldithio) pentanoate

    ADC Linkers Cancer
    SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate .
    SPP
  • HY-132252

    MP-PEG8-Val-Ala-PABC; MP-PEG8-VA-PABC

    ADC Linkers Cancer
    Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC .
    Mal-PEG8-Val-Ala-PABC
  • HY-42618

    ADC Linkers PROTAC Linkers Cancer
    Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-CH2-Boc
  • HY-132261

    4-(4-Acetyl-phenoxy)-butyric acid

    ADC Linkers Cancer
    AcBut (4-(4-Acetyl-phenoxy)-butyric acid) is a cleavable linker for Ozogamicin synthesis, and Ozogamicin is a drug-linker conjugate for ADC .
    AcBut
  • HY-145951

    Drug-Linker Conjugates for ADC Cancer
    Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs .
    Amidate-VC-PAB-MMAF
  • HY-118808

    ADC Linkers PROTAC Linkers Cancer
    Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHBoc
  • HY-W129833

    ADC Linkers Cancer
    H-Asp-Gly-OH is a cleavable ADC linker.
    H-Asp-Gly-OH
  • HY-W614632

    ADC Linkers Cancer
    γ-Glu-Val-Gly is a cleavable ADC linker.
    γ-Glu-Val-Gly
  • HY-49223

    ADC Linkers Cancer
    diMal-O-CH2COOH is a cleavable ADC linker.
    diMal-O-CH2COOH
  • HY-W591374

    ADC Linkers Cancer
    DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.
    DBCO-PEG4-Val-Ala-PAB-PNP
  • HY-129368
    SPDMV
    1 Publications Verification

    ADC Linkers Cancer
    SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
    SPDMV
  • HY-126405

    ADC Linkers Cancer
    SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    SMPT
  • HY-126893

    PROTAC Linkers ADC Linkers Cancer
    Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Bis-PEG8-acid
  • HY-140149

    ADC Linkers PROTAC Linkers Cancer
    Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-Val-Cit-PAB-OH
  • HY-145736A

    Drug-Linker Conjugates for ADC Apoptosis Cancer
    β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .
    β-Glucuronide-dPBD-PEG5-NH2 TFA
  • HY-126530

    ADC Linkers Cardiovascular Disease Cancer
    PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC) .
    PPC-NB
  • HY-148463

    ADC Linkers Cancer
    MP-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
    MP-Ala-Ala-PAB
  • HY-130222

    ADC Linkers PROTAC Linkers Cancer
    Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-Val-Cit-PAB-OH
  • HY-131955

    ADC Linkers Cancer
    Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-aminooxy-PEG2-NH2
  • HY-126892

    PROTAC Linkers ADC Linkers Cancer
    Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Bis-PEG7-acid
  • HY-130387

    PROTAC Linkers ADC Linkers Cancer
    Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Tos
  • HY-42489

    ADC Linkers PROTAC Linkers Cancer
    N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2-Boc
  • HY-145736

    Drug-Linker Conjugates for ADC Apoptosis Cancer
    β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .
    β-Glucuronide-dPBD-PEG5-NH2

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