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Cat. No.: HY-141220

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m-PEG12-OH

Name: m-PEG12-OH
Brand: MedChemExpress
SKU: HY-141220
Price: 36.00 USD
Availability: InStock
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m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Pureté: 99.59%
CAS No.: 2050595-03-2
Formule: C₂₅H₅₂O₁₃
Masse moléculaire:560.67

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

m-PEG12-OH Chemical Structure

CAS No.: 2050595-03-2

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- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Description

m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[2].

IC₅₀ & Target^[1]^[2]

PEGs	Non-cleavable Linker

Voir tous les produits spécifiques à Isoform PROTAC Linkers :

Voir tous les produits spécifiques à Isoform ADC Linkers :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2050595-03-2
Appearance Solid
Masse moléculaire 560.67
Formule C₂₅H₅₂O₁₃
Color Colorless to off-white
SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kachbi-Khelfallah S, et al. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J Org Chem. 2016 Jul 4;12:1366-71. [Content Brief]

[2]. Hamura, Mika, et al. Branched monodispersed polyethylene glycol, intermediate, and method for producing same. WO 2019181984 A1.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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m-PEG12-OH

m-PEG7-alcohol

Tetraethylene glycol monomethyl ether

Octaethylene glycol monomethyl ether

Nonaethylene glycol monomethyl ether

Hexaethylene glycol monomethyl ether

m-PEG3-OH

Pentaethylene glycol monomethyl ether

m-PEG8-NHS ester

m-PEG4-NHS ester

m-PEG5000-OH

m-PEG2000-OH

m-PEG1000-OH

Voir tous les produits spécifiques à Isoform PROTAC Linkers

Voir tous les produits spécifiques à Isoform ADC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

m-PEG12-OH

m-PEG7-alcohol

Tetraethylene glycol monomethyl ether

Octaethylene glycol monomethyl ether

Nonaethylene glycol monomethyl ether

Hexaethylene glycol monomethyl ether

m-PEG3-OH

Pentaethylene glycol monomethyl ether

m-PEG8-NHS ester

m-PEG4-NHS ester

m-PEG5000-OH

m-PEG2000-OH

m-PEG1000-OH

Voir tous les produits spécifiques à Isoform PROTAC Linkers

Voir tous les produits spécifiques à Isoform ADC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

m-PEG12-OH Related Classifications

HY-141220 Related Classifications

Bioz