1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. Bis-PEG5-NHS ester

Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis-PEG5-NHS ester Chemical Structure

Bis-PEG5-NHS ester Chemical Structure

CAS No. : 756526-03-1

Size Price Stock Quantity
25 mg USD 36 In-stock
50 mg USD 58 In-stock
100 mg USD 92 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

532.50

Formula

C22H32N2O13

CAS No.
Appearance

Viscous Liquid

Color

White to light brown

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (187.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8779 mL 9.3897 mL 18.7793 mL
5 mM 0.3756 mL 1.8779 mL 3.7559 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8779 mL 9.3897 mL 18.7793 mL 46.9484 mL
5 mM 0.3756 mL 1.8779 mL 3.7559 mL 9.3897 mL
10 mM 0.1878 mL 0.9390 mL 1.8779 mL 4.6948 mL
15 mM 0.1252 mL 0.6260 mL 1.2520 mL 3.1299 mL
20 mM 0.0939 mL 0.4695 mL 0.9390 mL 2.3474 mL
25 mM 0.0751 mL 0.3756 mL 0.7512 mL 1.8779 mL
30 mM 0.0626 mL 0.3130 mL 0.6260 mL 1.5649 mL
40 mM 0.0469 mL 0.2347 mL 0.4695 mL 1.1737 mL
50 mM 0.0376 mL 0.1878 mL 0.3756 mL 0.9390 mL
60 mM 0.0313 mL 0.1565 mL 0.3130 mL 0.7825 mL
80 mM 0.0235 mL 0.1174 mL 0.2347 mL 0.5869 mL
100 mM 0.0188 mL 0.0939 mL 0.1878 mL 0.4695 mL
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Bis-PEG5-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Bis-PEG5-NHS ester
Cat. No.:
HY-126889
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