2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MC-betaglucuronide-MMAE-2

MC-betaglucuronide-MMAE-2 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

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MC-betaglucuronide-MMAE-2

MC-betaglucuronide-MMAE-2 Estructura química

No. CAS : 1703778-81-7

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Based on 1 publication(s) in Google Scholar

MC-betaglucuronide-MMAE-2 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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Descripciòn

MC-betaglucuronide-MMAE-2 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-betaglucuronide-MMAE-2 Related Antibodies
Peso molecular

1296.46

Fòrmula

C63H93N9O20
No. CAS
Appearance

Solid

SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC([C@H](CN)N3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvente y solubilidad
In Vitro: 

DMSO : ≥ 100 mg/mL (77.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7713 mL 3.8567 mL 7.7133 mL
5 mM 0.1543 mL 0.7713 mL 1.5427 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7713 mL 3.8567 mL 7.7133 mL 19.2833 mL
5 mM 0.1543 mL 0.7713 mL 1.5427 mL 3.8567 mL
10 mM 0.0771 mL 0.3857 mL 0.7713 mL 1.9283 mL
15 mM 0.0514 mL 0.2571 mL 0.5142 mL 1.2856 mL
20 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9642 mL
25 mM 0.0309 mL 0.1543 mL 0.3085 mL 0.7713 mL
30 mM 0.0257 mL 0.1286 mL 0.2571 mL 0.6428 mL
40 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
50 mM 0.0154 mL 0.0771 mL 0.1543 mL 0.3857 mL
60 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3214 mL
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MC-betaglucuronide-MMAE-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-betaglucuronide-MMAE-21703778-81-7Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Nombre del producto:
MC-betaglucuronide-MMAE-2
Cat. No.:
HY-136321
Cantidad:
MCE Japan Authorized Agent:

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