1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Propargyl-PEG2-amine

Propargyl-PEG2-amine 

Cat. No.: HY-W051634
Handling Instructions

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Propargyl-PEG2-amine Chemical Structure

Propargyl-PEG2-amine Chemical Structure

CAS No. : 944561-44-8

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Description

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

IC50 & Target

Non-cleavable

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

143.18

Formula

C₇H₁₃NO₂

CAS No.

944561-44-8

SMILES

NCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

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Keywords:

Propargyl-PEG2-amineADC LinkerPROTAC LinkerAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatesPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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Propargyl-PEG2-amine
Cat. No.:
HY-W051634
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