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Cat. No.: HY-128927

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Mc-Leu-Gly-Arg

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.

For research use only. We do not sell to patients.

CAS No.: 2639874-49-8
Formula: C₂₁H₃₄N₆O₆
Molecular Weight:466.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Mc-Leu-Gly-Arg Chemical Structure

CAS No.: 2639874-49-8

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.

IC₅₀ & Target

Cleavable Linker

All ADC Linkers Isoforms :

Chemical Information

CAS No. 2639874-49-8
Molecular Weight 466.53
Formula C₂₁H₃₄N₆O₆
SMILES

O=C(O)[C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC(CCCCCN(C1=O)C(C=C1)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang D, et al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Mc-Leu-Gly-Arg

All ADC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mc-Leu-Gly-Arg Related Classifications

HY-128927 Related Classifications