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Cat. No.: HY-128927

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Mc-Leu-Gly-Arg

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.

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CAS No.: 2639874-49-8
Formule: C₂₁H₃₄N₆O₆
Masse moléculaire:466.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Mc-Leu-Gly-Arg Chemical Structure

CAS No.: 2639874-49-8

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.

IC₅₀ & Target

Cleavable Linker

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Chemical Information

CAS No. 2639874-49-8
Masse moléculaire 466.53
Formule C₂₁H₃₄N₆O₆
SMILES

O=C(O)[C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC(CCCCCN(C1=O)C(C=C1)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang D, et al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Mc-Leu-Gly-Arg

Voir tous les produits spécifiques à Isoform ADC Linkers