Trastuzumab-DM4
Based on 1 Customer Validation
Trastuzumab-DM4 is an antibody-drug conjugate (ADC) formed by conjugating Trastuzumab (HY-P9907) with DM4 (sulfo-SPDB-DM4) (HY-101141) via a cleavable linker. DM4 is a tubulin inhibitor that suppresses cell division. Trastuzumab-DM4 significantly inhibits tumor growth in Trastuzumab-resistant HER2 xenograft tumor models. Trastuzumab-DM4 can be used for the research of HER2-positive breast cancer.
For research use only. We do not sell to patients.
- Purity : 95.26%
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Storage:
-80°C, protect from light
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nu/nu (female)[1]
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Dosage:10 mg/kg
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Administration:i.v.; single injection
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Result:Significantly inhibited tumor growth.
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Trastuzumab-DM4]
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Trastuzumab-DM4
- Antibody-Drug Conjugates (ADCs)
- Microtubule/Tubulin
- trastuzumab-resistant HER2-overexpressing breast cancer mouse model
- HER2-overexpressing tumor cells
- her2-positive breast cancer
- BT-474 breast carcinoma cells
- MCF7 breast carcinoma cells
- beige nude mice
- SK-BR-3 breast carcinoma cells
- Inhibitor
- inhibitor
- inhibit