Mal-PEG2-Val-Cit-PABA-PNP
Based on 1 Customer Validation
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 95.68%
- CAS No.: 1345681-52-8
- Formule: C34H41N7O13
- Masse moléculaire:755.73
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Protease Cleavable Linker |
Cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1345681-52-8
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Appearance Solid
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Masse moléculaire 755.73
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Formule C34H41N7O13
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Color White to off-white
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SMILES
O=C(OC1=CC=C(C=C1)[N+]([O-])=O)OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OCCOCCN3C(C=CC3=O)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (132.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3232 mL | 6.6161 mL | 13.2322 mL | 33.0806 mL |
| 5 mM | 0.2646 mL | 1.3232 mL | 2.6464 mL | 6.6161 mL | |
| 10 mM | 0.1323 mL | 0.6616 mL | 1.3232 mL | 3.3081 mL | |
| 15 mM | 0.0882 mL | 0.4411 mL | 0.8821 mL | 2.2054 mL | |
| 20 mM | 0.0662 mL | 0.3308 mL | 0.6616 mL | 1.6540 mL | |
| 25 mM | 0.0529 mL | 0.2646 mL | 0.5293 mL | 1.3232 mL | |
| 30 mM | 0.0441 mL | 0.2205 mL | 0.4411 mL | 1.1027 mL | |
| 40 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8270 mL | |
| 50 mM | 0.0265 mL | 0.1323 mL | 0.2646 mL | 0.6616 mL | |
| 60 mM | 0.0221 mL | 0.1103 mL | 0.2205 mL | 0.5513 mL | |
| 80 mM | 0.0165 mL | 0.0827 mL | 0.1654 mL | 0.4135 mL | |
| 100 mM | 0.0132 mL | 0.0662 mL | 0.1323 mL | 0.3308 mL |
Mal-PEG2-Val-Cit-PABA-PNP Related Classifications
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