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Cat. No.: HY-W590556

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Endo-BCN-PEG4-Val-Cit-PAB-MMAF

Name: Endo-BCN-PEG4-Val-Cit-PAB-MMAF
Brand: MedChemExpress
SKU: HY-W590556
Price: 360.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

Endo-BCN-PEG4-Val-Cit-PAB-MMAF is a cleavable ADC linker conjugated with drug containing 4-unit PEG, which can be used for synthesizing antibody-drug conjugates (ADCs). endo-BCN-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Formula: C₈₀H₁₂₅N₁₁O₂₀
Molecular Weight:1560.91

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Data Sheet (267 KB)

Endo-BCN-PEG4-Val-Cit-PAB-MMAF Chemical Structure

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Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 1560.91
Formula C₈₀H₁₂₅N₁₁O₂₀
SMILES

O=C(NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC(C=C1)=CC=C1COC(N([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(N2CCC[C@H]2[C@@H]([C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C)OC)=O)OC)[C@@H](C)CC)C)=O)C(C)C)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)=O)OC[C@H]4[C@]5([H])[C@@]4([H])CCC#CCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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Endo-BCN-PEG4-Val-Cit-PAB-MMAF

All Drug-Linker Conjugates for ADC Isoforms