Gly-Gly-Gly-PEG4-methyltetrazine

Name: Gly-Gly-Gly-PEG4-methyltetrazine
Brand: MedChemExpress
SKU: HY-141284
Rating: 4.5 (0 reviews)

製品番号: HY-141284 純度: 99.20%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Gly-Gly-Gly-PEG4-methyltetrazine 構造式

CAS 番号 : 2353409-82-0

容量	価格（税別）	在庫状況	数量
5 mg	$210	在庫あり	Estimated Time of Arrival: December 31
10 mg	$340	在庫あり	Estimated Time of Arrival: December 31
25 mg	$680	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1100	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Gly-Gly-Gly-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

Cleavable Linker

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

534.57

分子式

C₂₃H₃₄N₈O₇

CAS 番号

2353409-82-0

Appearance

Solid

Color

Purple to purplish red

SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCNC(CNC(CNC(CN)=O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (187.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8707 mL	9.3533 mL	18.7066 mL
5 mM	0.3741 mL	1.8707 mL	3.7413 mL
10 mM	0.1871 mL	0.9353 mL	1.8707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.20%

Select Batch:

データシート (266 KB) SDS (394 KB)

COA (242 KB) HNMR (367 KB) RP-HPLC (260 KB) MS (234 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8707 mL	9.3533 mL	18.7066 mL	46.7666 mL
	5 mM	0.3741 mL	1.8707 mL	3.7413 mL	9.3533 mL
	10 mM	0.1871 mL	0.9353 mL	1.8707 mL	4.6767 mL
	15 mM	0.1247 mL	0.6236 mL	1.2471 mL	3.1178 mL
	20 mM	0.0935 mL	0.4677 mL	0.9353 mL	2.3383 mL
	25 mM	0.0748 mL	0.3741 mL	0.7483 mL	1.8707 mL
	30 mM	0.0624 mL	0.3118 mL	0.6236 mL	1.5589 mL
	40 mM	0.0468 mL	0.2338 mL	0.4677 mL	1.1692 mL
	50 mM	0.0374 mL	0.1871 mL	0.3741 mL	0.9353 mL
	60 mM	0.0312 mL	0.1559 mL	0.3118 mL	0.7794 mL
	80 mM	0.0234 mL	0.1169 mL	0.2338 mL	0.5846 mL
	100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.4677 mL