Mc-Val-Cit-PAB-Cl
Based on 1 Customer Validation
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1639351-92-0
- Formula: C28H39ClN6O6
- Molecular Weight:591.10
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1639351-92-0
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Appearance Solid
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Molecular Weight 591.10
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Formula C28H39ClN6O6
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Color White to off-white
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SMILES
O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CCl)C=C2)=O)=O)=O)C=CC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (169.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6918 mL | 8.4588 mL | 16.9176 mL | 42.2940 mL |
| 5 mM | 0.3384 mL | 1.6918 mL | 3.3835 mL | 8.4588 mL | |
| 10 mM | 0.1692 mL | 0.8459 mL | 1.6918 mL | 4.2294 mL | |
| 15 mM | 0.1128 mL | 0.5639 mL | 1.1278 mL | 2.8196 mL | |
| 20 mM | 0.0846 mL | 0.4229 mL | 0.8459 mL | 2.1147 mL | |
| 25 mM | 0.0677 mL | 0.3384 mL | 0.6767 mL | 1.6918 mL | |
| 30 mM | 0.0564 mL | 0.2820 mL | 0.5639 mL | 1.4098 mL | |
| 40 mM | 0.0423 mL | 0.2115 mL | 0.4229 mL | 1.0574 mL | |
| 50 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8459 mL | |
| 60 mM | 0.0282 mL | 0.1410 mL | 0.2820 mL | 0.7049 mL | |
| 80 mM | 0.0211 mL | 0.1057 mL | 0.2115 mL | 0.5287 mL | |
| 100 mM | 0.0169 mL | 0.0846 mL | 0.1692 mL | 0.4229 mL |
Mc-Val-Cit-PAB-Cl Related Classifications
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