2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mc-Val-Cit-PAB-Cl

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

For research use only. We do not sell to patients.

Mc-Val-Cit-PAB-Cl Chemical Structure

Mc-Val-Cit-PAB-Cl Chemical Structure

CAS No. : 1639351-92-0

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5 mg USD 360 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Mc-Val-Cit-PAB-Cl Related Antibodies

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Description

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

Molecular Weight

591.10

Formula

C28H39ClN6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CCl)C=C2)=O)=O)=O)C=CC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6918 mL 8.4588 mL 16.9176 mL
5 mM 0.3384 mL 1.6918 mL 3.3835 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6918 mL 8.4588 mL 16.9176 mL 42.2940 mL
5 mM 0.3384 mL 1.6918 mL 3.3835 mL 8.4588 mL
10 mM 0.1692 mL 0.8459 mL 1.6918 mL 4.2294 mL
15 mM 0.1128 mL 0.5639 mL 1.1278 mL 2.8196 mL
20 mM 0.0846 mL 0.4229 mL 0.8459 mL 2.1147 mL
25 mM 0.0677 mL 0.3384 mL 0.6767 mL 1.6918 mL
30 mM 0.0564 mL 0.2820 mL 0.5639 mL 1.4098 mL
40 mM 0.0423 mL 0.2115 mL 0.4229 mL 1.0574 mL
50 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8459 mL
60 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7049 mL
80 mM 0.0211 mL 0.1057 mL 0.2115 mL 0.5287 mL
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Mc-Val-Cit-PAB-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-Val-Cit-PAB-Cl1639351-92-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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