Mal-PEG2-Val-Cit-PAB-OH
Based on 1 Customer Validation
Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.49%
- No. CAS: 2055041-38-6
- Fòrmula: C29H42N6O9
- Peso molecular:618.68
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
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HY-20336
Mc-Val-Cit-PABC-PNPADC Linker -
HY-12362
Val-cit-PAB-OHADC Linker -
HY-41189
Fmoc-Val-Cit-PAB-PNPADC Linker -
HY-78738
MC-Val-Cit-PABADC Linker -
HY-19318
Fmoc-Val-Cit-PABADC Linker -
HY-141142
Boc-Val-Cit-PAB-PNPADC Linker -
HY-140145
Mal-PEG4-Val-Cit-PAB-PNPADC linker -
HY-141141
Boc-Val-Cit-PABADC Linker -
HY-140150
Azido-PEG3-Val-Cit-PAB-PNPADC Linker -
HY-140149
Azido-PEG4-Val-Cit-PAB-OHADC/PROTAC Linker -
HY-W038702
Boc-Val-Cit-OH -
HY-130944
Mal-PEG1-Val-Cit-PABC-OHADC Linker
Ver todos los productos específicos de isoformas ADC Linkers
MoreVer todos los productos específicos de isoformas PROTAC Linkers
More
Actividad biológica
Descripciòn
IC50 & Target
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Cleavable Linker |
Protease Cleavable Linker |
PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2055041-38-6
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Appearance Solid
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Peso molecular 618.68
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Fòrmula C29H42N6O9
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Color White to off-white
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SMILES
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN2C(C=CC2=O)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (202.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (242 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6163 mL | 8.0817 mL | 16.1634 mL | 40.4086 mL |
| 5 mM | 0.3233 mL | 1.6163 mL | 3.2327 mL | 8.0817 mL | |
| 10 mM | 0.1616 mL | 0.8082 mL | 1.6163 mL | 4.0409 mL | |
| 15 mM | 0.1078 mL | 0.5388 mL | 1.0776 mL | 2.6939 mL | |
| 20 mM | 0.0808 mL | 0.4041 mL | 0.8082 mL | 2.0204 mL | |
| 25 mM | 0.0647 mL | 0.3233 mL | 0.6465 mL | 1.6163 mL | |
| 30 mM | 0.0539 mL | 0.2694 mL | 0.5388 mL | 1.3470 mL | |
| 40 mM | 0.0404 mL | 0.2020 mL | 0.4041 mL | 1.0102 mL | |
| 50 mM | 0.0323 mL | 0.1616 mL | 0.3233 mL | 0.8082 mL | |
| 60 mM | 0.0269 mL | 0.1347 mL | 0.2694 mL | 0.6735 mL | |
| 80 mM | 0.0202 mL | 0.1010 mL | 0.2020 mL | 0.5051 mL | |
| 100 mM | 0.0162 mL | 0.0808 mL | 0.1616 mL | 0.4041 mL |
Mal-PEG2-Val-Cit-PAB-OH Related Classifications
HY-130222 Related Classifications
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