Eicosanedioic acid

Name: Eicosanedioic acid
Brand: MedChemExpress
SKU: HY-W034595
Rating: 4.5 (1 reviews)

Cat. No.: HY-W034595 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

For research use only. We do not sell to patients.

Eicosanedioic acid Chemical Structure

CAS No. : 2424-92-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 40	In-stock	Estimated Time of Arrival: December 31
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10 g		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.51

Formula

C₂₀H₃₈O₄

CAS No.

2424-92-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCCCCCCCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (72.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9196 mL	14.5981 mL	29.1962 mL
5 mM	0.5839 mL	2.9196 mL	5.8392 mL
10 mM	0.2920 mL	1.4598 mL	2.9196 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (266 KB) SDS (392 KB)

COA (238 KB) HNMR (115 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9196 mL	14.5981 mL	29.1962 mL	72.9906 mL
	5 mM	0.5839 mL	2.9196 mL	5.8392 mL	14.5981 mL
	10 mM	0.2920 mL	1.4598 mL	2.9196 mL	7.2991 mL
	15 mM	0.1946 mL	0.9732 mL	1.9464 mL	4.8660 mL
	20 mM	0.1460 mL	0.7299 mL	1.4598 mL	3.6495 mL
	25 mM	0.1168 mL	0.5839 mL	1.1678 mL	2.9196 mL
	30 mM	0.0973 mL	0.4866 mL	0.9732 mL	2.4330 mL
	40 mM	0.0730 mL	0.3650 mL	0.7299 mL	1.8248 mL
	50 mM	0.0584 mL	0.2920 mL	0.5839 mL	1.4598 mL
	60 mM	0.0487 mL	0.2433 mL	0.4866 mL	1.2165 mL