2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. TCO-SS-amine

TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

TCO-SS-amine Chemical Structure

TCO-SS-amine Chemical Structure

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5 mg USD 380 In-stock
10 mg USD 600 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

TCO-SS-amine Related Antibodies

Top Publications Citing Use of Products

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Description

TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-SS-amine Related Antibodies
Molecular Weight

304.47

Formula

C13H24N2O2S2
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCSSCCN)O[C@@H]1CC/C=C([H])/CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (821.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2844 mL 16.4220 mL 32.8440 mL
5 mM 0.6569 mL 3.2844 mL 6.5688 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (244 KB) HNMR (261 KB) MS (76 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2844 mL 16.4220 mL 32.8440 mL 82.1099 mL
5 mM 0.6569 mL 3.2844 mL 6.5688 mL 16.4220 mL
10 mM 0.3284 mL 1.6422 mL 3.2844 mL 8.2110 mL
15 mM 0.2190 mL 1.0948 mL 2.1896 mL 5.4740 mL
20 mM 0.1642 mL 0.8211 mL 1.6422 mL 4.1055 mL
25 mM 0.1314 mL 0.6569 mL 1.3138 mL 3.2844 mL
30 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7370 mL
40 mM 0.0821 mL 0.4105 mL 0.8211 mL 2.0527 mL
50 mM 0.0657 mL 0.3284 mL 0.6569 mL 1.6422 mL
60 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
80 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0264 mL
100 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8211 mL
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TCO-SS-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-SS-amineADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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