1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. DBCO-​C6-​acid

DBCO-​C6-​acid 

Cat. No.: HY-121805 Purity: 95.38%
Handling Instructions

DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues.

For research use only. We do not sell to patients.

DBCO-​C6-​acid Chemical Structure

DBCO-​C6-​acid Chemical Structure

CAS No. : 1425485-72-8

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25 mg Check price and availability

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Description

DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues[1].

IC50 & Target[1]

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

333.38

Formula

C₂₁H₁₉NO₃

CAS No.

1425485-72-8

SMILES

O=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (299.96 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL
10 mM 0.3000 mL 1.4998 mL 2.9996 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.50 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DBCO-​C6-​acidADC LinkerAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatescarmaphycinanaloguesInhibitorinhibitorinhibit

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Product Name:
DBCO-​C6-​acid
Cat. No.:
HY-121805
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