Mal-PEG8-Val-Cit-PAB-MMAF
Based on 1 Customer Validation
Mal-PEG8-Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAF contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162).
For research use only. We do not sell to patients.
- Purity: 99.97%
- Formula: C81H129N11O24
- Molecular Weight:1640.95
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 1640.95
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Formula C81H129N11O24
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Color White to off-white
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SMILES
O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O)N[C@H](C(N[C@H](C(NC2=CC=C(COC(N([C@H](C(N[C@H](C(N([C@H]([C@@H](CC(N3[C@]([H])([C@@H]([C@H](C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)C)OC)CCC3)=O)OC)[C@H](CC)C)C)=O)C(C)C)=O)C(C)C)C)=O)C=C2)=O)CCCNC(N)=O)=O)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (60.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6094 mL | 3.0470 mL | 6.0940 mL | 15.2351 mL |
| 5 mM | 0.1219 mL | 0.6094 mL | 1.2188 mL | 3.0470 mL | |
| 10 mM | 0.0609 mL | 0.3047 mL | 0.6094 mL | 1.5235 mL | |
| 15 mM | 0.0406 mL | 0.2031 mL | 0.4063 mL | 1.0157 mL | |
| 20 mM | 0.0305 mL | 0.1524 mL | 0.3047 mL | 0.7618 mL | |
| 25 mM | 0.0244 mL | 0.1219 mL | 0.2438 mL | 0.6094 mL | |
| 30 mM | 0.0203 mL | 0.1016 mL | 0.2031 mL | 0.5078 mL | |
| 40 mM | 0.0152 mL | 0.0762 mL | 0.1524 mL | 0.3809 mL | |
| 50 mM | 0.0122 mL | 0.0609 mL | 0.1219 mL | 0.3047 mL | |
| 60 mM | 0.0102 mL | 0.0508 mL | 0.1016 mL | 0.2539 mL |
Mal-PEG8-Val-Cit-PAB-MMAF Related Classifications
HY-156758 Related Classifications
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