2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Val-Ala-PABC-Exatecan trifluoroacetate

Val-Ala-PABC-Exatecan trifluoroacetate 

Cat. No.: HY-147095A Purity: 98.39%
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Val-Ala-PABC-Exatecan trifluoroacetate is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor, HY-13631). Val-Ala-PABC-Exatecan trifluoroacetate can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan.

For research use only. We do not sell to patients.

Val-Ala-PABC-Exatecan trifluoroacetate Chemical Structure

Val-Ala-PABC-Exatecan trifluoroacetate Chemical Structure

CAS No. : 2928571-45-1

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5 mg USD 650 In-stock
10 mg USD 1100 In-stock
25 mg USD 2200 In-stock
50 mg USD 3500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Val-Ala-PABC-Exatecan trifluoroacetate:

Val-Ala-PABC-Exatecan trifluoroacetate Related Antibodies

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Description

Val-Ala-PABC-Exatecan trifluoroacetate is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor, HY-13631). Val-Ala-PABC-Exatecan trifluoroacetate can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan[1].

Molecular Weight

868.83

Formula

C42H44F4N6O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)=O)=C4CN3C2=O)C)=O)O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (57.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1510 mL 5.7549 mL 11.5097 mL
5 mM 0.2302 mL 1.1510 mL 2.3019 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1510 mL 5.7549 mL 11.5097 mL 28.7743 mL
5 mM 0.2302 mL 1.1510 mL 2.3019 mL 5.7549 mL
10 mM 0.1151 mL 0.5755 mL 1.1510 mL 2.8774 mL
15 mM 0.0767 mL 0.3837 mL 0.7673 mL 1.9183 mL
20 mM 0.0575 mL 0.2877 mL 0.5755 mL 1.4387 mL
25 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1510 mL
30 mM 0.0384 mL 0.1918 mL 0.3837 mL 0.9591 mL
40 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7194 mL
50 mM 0.0230 mL 0.1151 mL 0.2302 mL 0.5755 mL
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Val-Ala-PABC-Exatecan trifluoroacetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Ala-PABC-Exatecan2928571-45-1Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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