Val-Ala-PABC-Exatecan
Based on 1 publication(s) in Google Scholar
Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Val-Ala-PABC-Exatecan can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan.
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- Reinheit: 99.90%
- CAS. Nr.: 2845164-91-0
- Formel: C40H43FN6O8
- Molecular Weight:754.80
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Val-Ala-PABC-Exatecan
MoreAlle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen
MoreAlle Topoisomerase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
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Camptothecins |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2845164-91-0
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Appearance Solid
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Molecular Weight 754.80
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Formel C40H43FN6O8
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Color Light yellow to brown
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SMILES
CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)=O)=C4CN3C2=O)C)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Res Sq
Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory Properties. [Abstract]2026 Apr 24:rs.3.rs-9194287. PMID: 42078873
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (132.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3249 mL | 6.6243 mL | 13.2485 mL | 33.1214 mL |
| 5 mM | 0.2650 mL | 1.3249 mL | 2.6497 mL | 6.6243 mL | |
| 10 mM | 0.1325 mL | 0.6624 mL | 1.3249 mL | 3.3121 mL | |
| 15 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2081 mL | |
| 20 mM | 0.0662 mL | 0.3312 mL | 0.6624 mL | 1.6561 mL | |
| 25 mM | 0.0530 mL | 0.2650 mL | 0.5299 mL | 1.3249 mL | |
| 30 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 40 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8280 mL | |
| 50 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6624 mL | |
| 60 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL | |
| 80 mM | 0.0166 mL | 0.0828 mL | 0.1656 mL | 0.4140 mL | |
| 100 mM | 0.0132 mL | 0.0662 mL | 0.1325 mL | 0.3312 mL |
Val-Ala-PABC-Exatecan Related Classifications
HY-147095 Related Classifications
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