Val-Ala-PABC-Exatecan
Based on 1 publication(s) in Google Scholar
Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Val-Ala-PABC-Exatecan can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan.
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- Pureza : 99.90%
- No. CAS: 2845164-91-0
- Fòrmula: C40H43FN6O8
- Peso molecular:754.80
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Val-Ala-PABC-Exatecan
MoreVer todos los productos específicos de isoformas Drug-Linker Conjugates for ADC
MoreVer todos los productos específicos de isoformas Topoisomerase
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Actividad biológica
Descripciòn
IC50 & Target
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Camptothecins |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2845164-91-0
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Appearance Solid
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Peso molecular 754.80
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Fòrmula C40H43FN6O8
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Color Light yellow to brown
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SMILES
CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)=O)=C4CN3C2=O)C)=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Res Sq
Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory Properties. [Abstract]2026 Apr 24:rs.3.rs-9194287. PMID: 42078873
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (132.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3249 mL | 6.6243 mL | 13.2485 mL | 33.1214 mL |
| 5 mM | 0.2650 mL | 1.3249 mL | 2.6497 mL | 6.6243 mL | |
| 10 mM | 0.1325 mL | 0.6624 mL | 1.3249 mL | 3.3121 mL | |
| 15 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2081 mL | |
| 20 mM | 0.0662 mL | 0.3312 mL | 0.6624 mL | 1.6561 mL | |
| 25 mM | 0.0530 mL | 0.2650 mL | 0.5299 mL | 1.3249 mL | |
| 30 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 40 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8280 mL | |
| 50 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6624 mL | |
| 60 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL | |
| 80 mM | 0.0166 mL | 0.0828 mL | 0.1656 mL | 0.4140 mL | |
| 100 mM | 0.0132 mL | 0.0662 mL | 0.1325 mL | 0.3312 mL |
Val-Ala-PABC-Exatecan Related Classifications
HY-147095 Related Classifications
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