MC-VC-PAB-Cyclohexanediamine-Thailanstatin A

Cat. No.: HY-153601 Purity: 92.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a Spliceostatin (HY-16466) analog, and a drug-linker conjugates for ADC, consisting of ADC Cytotoxin Thailanstatin A (HY-129589) and cleavable ADC linker (MC-vc-PAB). MC-VC-PAB-Cyclohexanediamine-Thailanstatin A can be used for ADC synthesis.

For research use only. We do not sell to patients.

MC-VC-PAB-Cyclohexanediamine-Thailanstatin A Chemical Structure

CAS No. : 1609108-96-4

Size	Price	Stock	Quantity
1 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2200	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1230.45

Formula

C₆₃H₉₁N₉O₁₆

CAS No.

1609108-96-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2(C[C@H](O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(C)=O)=O)C)CC(N[C@@H]4CC[C@H](CC4)NC(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)=O)=O)CO2

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

DMSO : 85 mg/mL (69.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8127 mL	4.0636 mL	8.1271 mL
5 mM	0.1625 mL	0.8127 mL	1.6254 mL
10 mM	0.0813 mL	0.4064 mL	0.8127 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 92.11%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (253 KB) HNMR (307 KB) RP-HPLC (230 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Dirico KJ, et al. Preparation of spliceostatin analog antibody conjugates for cancer treatment. World Intellectual Property Organization, WO2014068443 A1. 2014-05-08.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8127 mL	4.0636 mL	8.1271 mL	20.3178 mL
	5 mM	0.1625 mL	0.8127 mL	1.6254 mL	4.0636 mL
	10 mM	0.0813 mL	0.4064 mL	0.8127 mL	2.0318 mL
	15 mM	0.0542 mL	0.2709 mL	0.5418 mL	1.3545 mL
	20 mM	0.0406 mL	0.2032 mL	0.4064 mL	1.0159 mL
	25 mM	0.0325 mL	0.1625 mL	0.3251 mL	0.8127 mL
	30 mM	0.0271 mL	0.1355 mL	0.2709 mL	0.6773 mL
	40 mM	0.0203 mL	0.1016 mL	0.2032 mL	0.5079 mL
	50 mM	0.0163 mL	0.0813 mL	0.1625 mL	0.4064 mL
	60 mM	0.0135 mL	0.0677 mL	0.1355 mL	0.3386 mL