1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Azido-PEG5-alcohol

Azido-PEG5-alcohol 

Cat. No.: HY-130211
Handling Instructions

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Azido-PEG5-alcohol Chemical Structure

Azido-PEG5-alcohol Chemical Structure

CAS No. : 86770-68-5

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Description

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target[1][2]

PEGs

 

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Molecular Weight

263.29

Formula

C₁₀H₂₁N₃O₅

CAS No.

86770-68-5

SMILES

OCCOCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Azido-PEG5-alcoholADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACnon-cleavableInhibitorinhibitorinhibit

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Azido-PEG5-alcohol
Cat. No.:
HY-130211
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