2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MC-Gly-Gly-Phe-Gly

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MC-Gly-Gly-Phe-Gly Chemical Structure

MC-Gly-Gly-Phe-Gly Chemical Structure

CAS No. : 2413428-36-9

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Based on 1 publication(s) in Google Scholar

MC-Gly-Gly-Phe-Gly Related Antibodies

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Description

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable Linker

 

Molecular Weight

529.54

Formula

C25H31N5O8
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC(O)=O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (236.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8884 mL 9.4422 mL 18.8843 mL
5 mM 0.3777 mL 1.8884 mL 3.7769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.94%

COA (245 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8884 mL 9.4422 mL 18.8843 mL 47.2108 mL
5 mM 0.3777 mL 1.8884 mL 3.7769 mL 9.4422 mL
10 mM 0.1888 mL 0.9442 mL 1.8884 mL 4.7211 mL
15 mM 0.1259 mL 0.6295 mL 1.2590 mL 3.1474 mL
20 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3605 mL
25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8884 mL
30 mM 0.0629 mL 0.3147 mL 0.6295 mL 1.5737 mL
40 mM 0.0472 mL 0.2361 mL 0.4721 mL 1.1803 mL
50 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL
60 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7868 mL
80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5901 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4721 mL
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MC-Gly-Gly-Phe-Gly Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe-Gly2413428-36-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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