2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MC-Gly-Gly-Phe-Gly

MC-Gly-Gly-Phe-Gly  (Synonyms: Mc-GGFG-OH)

Cat. No.: HY-44246 Purity: 98.02%
COA
SDS
Handling Instructions Technical Support

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

MC-Gly-Gly-Phe-Gly

MC-Gly-Gly-Phe-Gly 화학구조

CAS No. : 2413428-36-9

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
1 g 해외재고보유
5 g 해외재고보유
10 g   견적 받기  
50 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

MC-Gly-Gly-Phe-Gly Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

View All Isoforms
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Biological Activity

  • 순도&문서

  • 고객리뷰

제품 설명

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-Gly-Gly-Phe-Gly Related Antibodies
분자량

529.54

화학식

C25H31N5O8
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC(O)=O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도
In Vitro: 

DMSO : 116.67 mg/mL (220.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8884 mL 9.4422 mL 18.8843 mL
5 mM 0.3777 mL 1.8884 mL 3.7769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.02%

SDS (393 KB)

COA (246 KB) HNMR (306 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8884 mL 9.4422 mL 18.8843 mL 47.2108 mL
5 mM 0.3777 mL 1.8884 mL 3.7769 mL 9.4422 mL
10 mM 0.1888 mL 0.9442 mL 1.8884 mL 4.7211 mL
15 mM 0.1259 mL 0.6295 mL 1.2590 mL 3.1474 mL
20 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3605 mL
25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8884 mL
30 mM 0.0629 mL 0.3147 mL 0.6295 mL 1.5737 mL
40 mM 0.0472 mL 0.2361 mL 0.4721 mL 1.1803 mL
50 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL
60 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7868 mL
80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5901 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4721 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MC-Gly-Gly-Phe-Gly Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe-Gly2413428-36-9Mc-GGFG-OHADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
MC-Gly-Gly-Phe-Gly
Cat. No.:
HY-44246
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.