MC-Gly-Gly-Phe-Gly
Based on 2 publication(s) in Google Scholar
MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 98.64%
- CAS No.: 2413428-36-9
- Formula: C25H31N5O8
- Molecular Weight:529.54
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Deruxtecan
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HY-41189
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HY-140889
Biotin-PEG4-NHS ester
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HY-13631EG
Deruxtecan (GMP)
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HY-12362G
Val-cit-PAB-OH (GMP)
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HY-20336G
Mc-Val-Cit-PABC-PNP (GMP)
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HY-141192
N-Boc-PEG8-alcohol
Publications Citing Use of MedChemExpress (MCE) MC-Gly-Gly-Phe-Gly
More
Biological Activity
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Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413428-36-9
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Appearance Solid
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Molecular Weight 529.54
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Formula C25H31N5O8
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Color White to yellow
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SMILES
O=C(NCC(O)=O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
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Synonyms
Mc-GGFG-OH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
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Journal Impact Factor
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Most Recent
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Mol Cancer Ther
A DXd/TLR7-agonist dual-conjugate anti-HER2 ADC exerts robust anti-tumor activity through tumor cell killing and immune activation. [Abstract]2024 Nov 4;23(11):1639-1651. PMID: 39082754 -
Solvent & Solubility
DMSO : 116.67 mg/mL (220.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8884 mL | 9.4422 mL | 18.8843 mL | 47.2108 mL |
| 5 mM | 0.3777 mL | 1.8884 mL | 3.7769 mL | 9.4422 mL | |
| 10 mM | 0.1888 mL | 0.9442 mL | 1.8884 mL | 4.7211 mL | |
| 15 mM | 0.1259 mL | 0.6295 mL | 1.2590 mL | 3.1474 mL | |
| 20 mM | 0.0944 mL | 0.4721 mL | 0.9442 mL | 2.3605 mL | |
| 25 mM | 0.0755 mL | 0.3777 mL | 0.7554 mL | 1.8884 mL | |
| 30 mM | 0.0629 mL | 0.3147 mL | 0.6295 mL | 1.5737 mL | |
| 40 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 1.1803 mL | |
| 50 mM | 0.0378 mL | 0.1888 mL | 0.3777 mL | 0.9442 mL | |
| 60 mM | 0.0315 mL | 0.1574 mL | 0.3147 mL | 0.7868 mL | |
| 80 mM | 0.0236 mL | 0.1180 mL | 0.2361 mL | 0.5901 mL | |
| 100 mM | 0.0189 mL | 0.0944 mL | 0.1888 mL | 0.4721 mL |
MC-Gly-Gly-Phe-Gly Related Classifications
HY-44246 Related Classifications
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