1. PROTAC
  2. PROTAC Linker
  3. Biotin-PEG4-NHS ester

Biotin-PEG4-NHS ester 

Cat. No.: HY-140889 Purity: 98.08%
Handling Instructions

Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG4-NHS ester Chemical Structure

Biotin-PEG4-NHS ester Chemical Structure

CAS No. : 459426-22-3

Size Price Stock Quantity
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
250 mg USD 480 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

588.67

Formula

C₂₅H₄₀N₄O₁₀S

CAS No.

459426-22-3

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(CCCC[[email protected]@H]2SC[[email protected]]([[email protected]]2([H])N3)([H])NC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (424.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6987 mL 8.4937 mL 16.9874 mL
5 mM 0.3397 mL 1.6987 mL 3.3975 mL
10 mM 0.1699 mL 0.8494 mL 1.6987 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Biotin-PEG4-NHS esterPROTAC LinkerInhibitorinhibitorinhibit

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Biotin-PEG4-NHS ester
Cat. No.:
HY-140889
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