DBCO-Val-Cit-PABC-PNP
Based on 1 Customer Validation
DBCO-Val-Cit-PABC-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- Pureté : 97.74%
- CAS No.: 2994332-18-0
- Formule: C46H49N7O10
- Masse moléculaire:859.92
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Protease Cleavable Linker |
Cleavable Linker |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2994332-18-0
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Appearance Solid
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Masse moléculaire 859.92
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Formule C46H49N7O10
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Color Off-white to light yellow
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SMILES
CC([C@@H](C(N[C@H](C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)CCCNC(N)=O)=O)NC(CCCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (116.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1629 mL | 5.8145 mL | 11.6290 mL | 29.0725 mL |
| 5 mM | 0.2326 mL | 1.1629 mL | 2.3258 mL | 5.8145 mL | |
| 10 mM | 0.1163 mL | 0.5814 mL | 1.1629 mL | 2.9072 mL | |
| 15 mM | 0.0775 mL | 0.3876 mL | 0.7753 mL | 1.9382 mL | |
| 20 mM | 0.0581 mL | 0.2907 mL | 0.5814 mL | 1.4536 mL | |
| 25 mM | 0.0465 mL | 0.2326 mL | 0.4652 mL | 1.1629 mL | |
| 30 mM | 0.0388 mL | 0.1938 mL | 0.3876 mL | 0.9691 mL | |
| 40 mM | 0.0291 mL | 0.1454 mL | 0.2907 mL | 0.7268 mL | |
| 50 mM | 0.0233 mL | 0.1163 mL | 0.2326 mL | 0.5814 mL | |
| 60 mM | 0.0194 mL | 0.0969 mL | 0.1938 mL | 0.4845 mL | |
| 80 mM | 0.0145 mL | 0.0727 mL | 0.1454 mL | 0.3634 mL | |
| 100 mM | 0.0116 mL | 0.0581 mL | 0.1163 mL | 0.2907 mL |
DBCO-Val-Cit-PABC-PNP Related Classifications
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