1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO)

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) Chemical Structure

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) Chemical Structure

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Description

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1205.39

Formula

C62H88N6O18

SMILES

O=C(CCC(NCCOCCOCCOCCN(C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CCOCCOCCOCCNC(O[C@H]2CCC/C([H])=C/CC2)=O)=O)N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO)
Cat. No.:
HY-136084
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