1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. SC-VC-PAB-MMAE

SC-VC-PAB-MMAE is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB.

For research use only. We do not sell to patients.

SC-VC-PAB-MMAE Chemical Structure

SC-VC-PAB-MMAE Chemical Structure

CAS No. : 2259318-46-0

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1 mg USD 350 In-stock
5 mg USD 1050 In-stock
10 mg USD 1500 In-stock
50 mg USD 3750 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SC-VC-PAB-MMAE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SC-VC-PAB-MMAE is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

1348.62

Formula

C68H105N11O17

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCC(ON1C(CCC1=O)=O)=O)=O)=O)NC(C=C2)=CC=C2COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)CCC3)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (74.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7415 mL 3.7075 mL 7.4150 mL
5 mM 0.1483 mL 0.7415 mL 1.4830 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.51%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7415 mL 3.7075 mL 7.4150 mL 18.5375 mL
5 mM 0.1483 mL 0.7415 mL 1.4830 mL 3.7075 mL
10 mM 0.0741 mL 0.3707 mL 0.7415 mL 1.8537 mL
15 mM 0.0494 mL 0.2472 mL 0.4943 mL 1.2358 mL
20 mM 0.0371 mL 0.1854 mL 0.3707 mL 0.9269 mL
25 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7415 mL
30 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.6179 mL
40 mM 0.0185 mL 0.0927 mL 0.1854 mL 0.4634 mL
50 mM 0.0148 mL 0.0741 mL 0.1483 mL 0.3707 mL
60 mM 0.0124 mL 0.0618 mL 0.1236 mL 0.3090 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SC-VC-PAB-MMAE
Cat. No.:
HY-126681
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