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Cat. No.: HY-W011277

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Fmoc-azetidine-3-carboxylic acid

Name: Fmoc-azetidine-3-carboxylic acid
Brand: MedChemExpress
SKU: HY-W011277
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 193693-64-0
Formula: C₁₉H₁₇NO₄
Molecular Weight:323.35

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Fmoc-azetidine-3-carboxylic acid Chemical Structure

CAS No.: 193693-64-0

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One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Non-cleavable Linker

All ADC Linkers Isoforms :

All PROTAC Linkers Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 193693-64-0
Appearance Solid
Molecular Weight 323.35
Formula C₁₉H₁₇NO₄
Color White to off-white
SMILES

C1=CC=CC2=C1C(C3=C2C=CC=C3)COC(=O)N4CC(C4)C(=O)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Fmoc-azetidine-3-carboxylic acid

1-N-Boc-3-hydroxyazetidine

tert-Butyl 3-oxoazetidine-1-carboxylate

L-Azetidine-2-carboxylic acid

Azetidin-3-ol hydrochloride

Azetidine hydrochloride

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid

Azetidine-2-carboxylic acid

Methyl azetidine-3-carboxylate hydrochloride

RRx-001

1-Boc-azetidine-3-yl-methanol

3-Fluoroazetidine hydrochloride

Methyl 1-Boc-azetidine-3-carboxylate

All ADC Linkers Isoforms

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Fmoc-azetidine-3-carboxylic acid

1-N-Boc-3-hydroxyazetidine

tert-Butyl 3-oxoazetidine-1-carboxylate

L-Azetidine-2-carboxylic acid

Azetidin-3-ol hydrochloride

Azetidine hydrochloride

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid

Azetidine-2-carboxylic acid

Methyl azetidine-3-carboxylate hydrochloride

RRx-001

1-Boc-azetidine-3-yl-methanol

3-Fluoroazetidine hydrochloride

Methyl 1-Boc-azetidine-3-carboxylate

All ADC Linkers Isoforms

All PROTAC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Fmoc-azetidine-3-carboxylic acid Related Classifications

HY-W011277 Related Classifications

Bioz