1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. NH2-PEG2-C2-Boc

NH2-PEG2-C2-Boc 

Cat. No.: HY-42149 Purity: >98.0%
Handling Instructions

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

NH2-PEG2-C2-Boc Chemical Structure

NH2-PEG2-C2-Boc Chemical Structure

CAS No. : 756525-95-8

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Description

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target

PEGs

 

Alkyl/ether

 

Non-cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Molecular Weight

233.30

Formula

C₁₁H₂₃NO₄

CAS No.

756525-95-8

SMILES

NCCOCCOCCC(OC(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NH2-PEG2-C2-BocPROTAC LinkerADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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NH2-PEG2-C2-Boc
Cat. No.:
HY-42149
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