756525-95-8
756525-95-8
Chemical Structure
NH2-PEG2-C2-Boc
- CAS No.: 756525-95-8
- Formula:C11H23NO4
- Molecular Weight:233.30
IUPAC Name: tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
InChIKey: XIVHGTLMLORWEP-UHFFFAOYSA-N
SMILES: NCCOCCOCCC(OC(C)(C)C)=O
Biological Activity: NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NH2-PEG2-C2-Boc | 98.0% | NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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References
- [1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964. [Content Brief]
- [2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.
