2. PROTAC
  3. PROTAC Linkers
  4. Methylamino-PEG2-Boc

Methylamino-PEG2-Boc  (Synonyms: Methylamino-PEG2-t-butyl ester)

Cat. No.: HY-140155 Purity: 99.96%
COA
SDS
Handling Instructions Technical Support

Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Methylamino-PEG2-Boc

Methylamino-PEG2-Boc Chemical Structure

CAS No. : 1807521-04-5

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Customer Review

Based on 1 publication(s) in Google Scholar

Methylamino-PEG2-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methylamino-PEG2-Boc Related Antibodies
Molecular Weight

247.33

Formula

C12H25NO4
CAS No.
Appearance

Liquid (Density: 0.982±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCNC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (202.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0432 mL 20.2159 mL 40.4318 mL
5 mM 0.8086 mL 4.0432 mL 8.0864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.96%

SDS (394 KB)

COA (241 KB) HNMR (232 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0432 mL 20.2159 mL 40.4318 mL 101.0795 mL
5 mM 0.8086 mL 4.0432 mL 8.0864 mL 20.2159 mL
10 mM 0.4043 mL 2.0216 mL 4.0432 mL 10.1080 mL
15 mM 0.2695 mL 1.3477 mL 2.6955 mL 6.7386 mL
20 mM 0.2022 mL 1.0108 mL 2.0216 mL 5.0540 mL
25 mM 0.1617 mL 0.8086 mL 1.6173 mL 4.0432 mL
30 mM 0.1348 mL 0.6739 mL 1.3477 mL 3.3693 mL
40 mM 0.1011 mL 0.5054 mL 1.0108 mL 2.5270 mL
50 mM 0.0809 mL 0.4043 mL 0.8086 mL 2.0216 mL
60 mM 0.0674 mL 0.3369 mL 0.6739 mL 1.6847 mL
80 mM 0.0505 mL 0.2527 mL 0.5054 mL 1.2635 mL
100 mM 0.0404 mL 0.2022 mL 0.4043 mL 1.0108 mL
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Methylamino-PEG2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylamino-PEG2-Boc1807521-04-5Methylamino-PEG2-t-butyl esterPROTAC LinkersInhibitorinhibitorinhibit

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