2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG2-C2-Boc

Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bromo-PEG2-C2-Boc Chemical Structure

Bromo-PEG2-C2-Boc Chemical Structure

CAS No. : 1381861-91-1

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Based on 1 publication(s) in Google Scholar

Bromo-PEG2-C2-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG2-C2-Boc Related Antibodies
Molecular Weight

297.19

Formula

C11H21BrO4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (336.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3649 mL 16.8243 mL 33.6485 mL
5 mM 0.6730 mL 3.3649 mL 6.7297 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3649 mL 16.8243 mL 33.6485 mL 84.1213 mL
5 mM 0.6730 mL 3.3649 mL 6.7297 mL 16.8243 mL
10 mM 0.3365 mL 1.6824 mL 3.3649 mL 8.4121 mL
15 mM 0.2243 mL 1.1216 mL 2.2432 mL 5.6081 mL
20 mM 0.1682 mL 0.8412 mL 1.6824 mL 4.2061 mL
25 mM 0.1346 mL 0.6730 mL 1.3459 mL 3.3649 mL
30 mM 0.1122 mL 0.5608 mL 1.1216 mL 2.8040 mL
40 mM 0.0841 mL 0.4206 mL 0.8412 mL 2.1030 mL
50 mM 0.0673 mL 0.3365 mL 0.6730 mL 1.6824 mL
60 mM 0.0561 mL 0.2804 mL 0.5608 mL 1.4020 mL
80 mM 0.0421 mL 0.2103 mL 0.4206 mL 1.0515 mL
100 mM 0.0336 mL 0.1682 mL 0.3365 mL 0.8412 mL
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Bromo-PEG2-C2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG2-C2-Boc1381861-91-1PROTAC LinkersInhibitorinhibitorinhibit

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