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Cat. No.: HY-126497

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LC-PEG8-SPDP

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

CAS No.: 1252257-56-9
Formula: C₃₁H₄₉N₃O₁₃S₂
Molecular Weight:735.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

LC-PEG8-SPDP Chemical Structure

CAS No.: 1252257-56-9

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target^[1]

Disulfide Cleavable Linker

Cleavable Linker

All ADC Linkers Isoforms :

Chemical Information

CAS No. 1252257-56-9
Molecular Weight 735.86
Formula C₃₁H₄₉N₃O₁₃S₂
SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCSSC2=NC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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