Azido-PEG4-Val-Cit-PAB-OH
Based on 1 Customer Validation
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 95.09%
- CAS No.: 2055024-64-9
- Formula: C29H48N8O9
- Molecular Weight:652.74
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-140150
Azido-PEG3-Val-Cit-PAB-PNP
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HY-20336
Mc-Val-Cit-PABC-PNP
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-78738
MC-Val-Cit-PAB
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HY-19318
Fmoc-Val-Cit-PAB
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HY-141142
Boc-Val-Cit-PAB-PNP
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HY-140145
Mal-PEG4-Val-Cit-PAB-PNP
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HY-141141
Boc-Val-Cit-PAB
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HY-W038702
Boc-Val-Cit-OH
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HY-130944
Mal-PEG1-Val-Cit-PABC-OH
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HY-140144
Mal-PEG1-Val-Cit-PAB-PNP
All PROTAC Linkers Isoforms
More
Biological Activity
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Protease Cleavable Linker |
PEGs |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055024-64-9
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Appearance Solid
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Molecular Weight 652.74
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Formula C29H48N8O9
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Color White to off-white
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SMILES
O=C(N)[C@H](CCCNC(N)=O)N(C([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)C1=CC=C(CO)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. [Content Brief]
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Azido-PEG4-Val-Cit-PAB-OH Related Classifications
HY-140149 Related Classifications
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