SC239
Based on 1 Customer Validation
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 1977557-97-3
- Formula: C65H84N10O11
- Molecular Weight:1181.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
SC239 is composed of a tubulin-targeting 3-aminophenyl hemiasterlin warhead, SC209 (HY-144880), and a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
The SC239 drug-linker is conjugated via a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
SC239 conjugates exhibits better cytotoxic activity on Igrov1 cells which have lower expression levels of FolRα[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1977557-97-3
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Appearance Solid
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Molecular Weight 1181.42
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Formula C65H84N10O11
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Color White to off-white
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SMILES
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(NC5=CC(C(C)(C)[C@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O)=CC=C5)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 75 mg/mL (63.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8464 mL | 4.2322 mL | 8.4644 mL | 21.1610 mL |
| 5 mM | 0.1693 mL | 0.8464 mL | 1.6929 mL | 4.2322 mL | |
| 10 mM | 0.0846 mL | 0.4232 mL | 0.8464 mL | 2.1161 mL | |
| 15 mM | 0.0564 mL | 0.2821 mL | 0.5643 mL | 1.4107 mL | |
| 20 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0580 mL | |
| 25 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8464 mL | |
| 30 mM | 0.0282 mL | 0.1411 mL | 0.2821 mL | 0.7054 mL | |
| 40 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5290 mL | |
| 50 mM | 0.0169 mL | 0.0846 mL | 0.1693 mL | 0.4232 mL | |
| 60 mM | 0.0141 mL | 0.0705 mL | 0.1411 mL | 0.3527 mL |
SC239 Related Classifications
HY-148194 Related Classifications
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