2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SC239

SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

SC239 Chemical Structure

SC239 Chemical Structure

CAS No. : 1977557-97-3

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1 mg USD 810 In-stock
5 mg USD 2040 In-stock
10 mg USD 3250 In-stock
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Based on 1 publication(s) in Google Scholar

SC239 Related Antibodies

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Description

SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC[1]. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

In Vitro

SC239 is composed of a tubulin-targeting 3-aminophenyl hemiasterlin warhead, SC209 (HY-144880), and a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
The SC239 drug-linker is conjugated via a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
SC239 conjugates exhibits better cytotoxic activity on Igrov1 cells which have lower expression levels of FolRα[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SC239 Related Antibodies
Molecular Weight

1181.42

Formula

C65H84N10O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(NC5=CC(C(C)(C)[C@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O)=CC=C5)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (63.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8464 mL 4.2322 mL 8.4644 mL
5 mM 0.1693 mL 0.8464 mL 1.6929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8464 mL 4.2322 mL 8.4644 mL 21.1610 mL
5 mM 0.1693 mL 0.8464 mL 1.6929 mL 4.2322 mL
10 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1161 mL
15 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4107 mL
20 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0580 mL
25 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8464 mL
30 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7054 mL
40 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
50 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.4232 mL
60 mM 0.0141 mL 0.0705 mL 0.1411 mL 0.3527 mL
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SC239 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC2391977557-97-3SC 239SC-239Drug-Linker Conjugates for ADCFolate receptor alphaFolRαDBCOADC drug-linkerIgrov1 cellsInhibitorinhibitorinhibit

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